Allergy and Asthma Centers of the NW
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Immunology and Infection

These abnormalities can present in many forms of disease, in both pediatric and adult patients. Children born with no immune system due to gene abnormalities usually present with early signs of infection within the first few years of life. Those infections are usually severe and could be life threatening. Failure to thrive could also be a sign of those abnormalities. These early presentations of immune disease are usually rare, but severe.

The late presentations of those abnormalities in adults are usually not as severe, but they are more common. The most likely presentation is:

  • Sinusitis
  • Otitis Media
  • Pneumonia
  • Bronchitis
  • Frequent Infections
  • Multiple Antibiotic Use

In those patients, the history of frequent antibiotic use and repetitive infections, such as sinusitis or bronchitis, might be the only suggested clues.

Immunoglobulin transfusion
This is a treatment that can help restore someone's immunity by transfusing a donor's immunity in the form of intravenous immunoglobulin (IgIV). This passive restoration needs to be done monthly, and may be given for life in children born without an immune system.  It can be for a short time (1-2 years) in adult cases, unless there is an underlying gene abnormality affecting the production of this immunity.

IV Drug Administration
Our center is certified and our providers are trained to handle immune modifying medications that treat a variety of other diseases.  Drugs we infuse at our site include:

  • Remicade
  • Other immune modifying drugs

These are given in many rheumatology and gastroenterology diseases, such as Crohn's Disease, ulcerative colitis, rheumatoid arthritis, psoriasis and many others. Our providers usually do not prescribe those medications to treat these diseases, but they can help your specialist administer the drugs to you.  For patients that are allergic to the medications, our providers are able to administer the drugs to them through a special protocol known as "desensitization". This allows an allergic patient to continue taking those important medications, preventing them from having to discontinue them, which may lead to a return of the symptoms or taking less effective drugs as a treatment.